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   DIVISION OF MALE REPRODUCTIVE MEDICINE AND SURGERY                   
My husband was found to have a b+c microdeletion on his Y chromosome, resulting in azoospermia. We are waiting to determine if it is partial or complete deletion. What would your recommendations be, as we would like to achieve pregnancy together without donor sperm. Thank you.

Sounds like a tough situation. For patients with AZFc mutations alone, the chance of finding sperm in the testis with surgery is decent (>50%), however, it is much lower and not well defined in patients with AZFa or AZFb mutations. So, while we often recommend using donor sperm or adoption, it is certainly an option to look for sperm using microTESE, although the success rate should be expected to be quite low. Hope that helps, and wishing you the best.